Searchable abstracts of presentations at key conferences in endocrinology

ea0092op-05-04 | Oral Session 5: Young Investigators / Basic | ETA2023

Multi-Trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

Sterenborg Rosalie , Steinbrenner Inga , Li Yong , Bujnis Melissa , Naito Tatsuhiko , Marouli Eirini , Consortium Thyroidomics , Kottgen Anna , Smit Johannes W.A. , Peeters Robin , Teumer Alexander , Medici Marco

Introduction: In the last decade, it has become clear that not only overt but also subclinical hypo- and hyperthyroidism are associated with several adverse clinical outcomes, including atrial fibrillation, coronary heart disease, stroke and mortality. More recently, various studies have suggested that even small differences in thyroid function within the reference range are associated with clinical consequences. Genetic factors are responsible for up to 58-71% of the variatio...